Brain-CODE proof point: Biomarkers may help personalize depression treatment

29 avril 2025

According to a recent article, finding the right antidepressant treatment can be a frustrating, time-consuming process – one that often requires individuals to endure weeks of ineffective medication before trying something new. Now, a new study supported by the National Institutes of Health, that uses a data set from OBI's Brain-CODE platform, offers hope for a more personalized approach.

Published in JAMA Network Open, the study reveals promising progress toward predicting how patients with major depressive disorder will respond to antidepressant medications using brain imaging and clinical data. The research demonstrated that brain connectivity patterns – specifically in the dorsal anterior cingulate cortex – could significantly improve predictions of treatment response across two large, independent clinical trials. > READ MORE